Super-TDU (TFA) (1599441-71-0 free base)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

uper-TDU is an inhibitory peptide targeting YAP-TEADs interaction.

uper-TDU is an inhibitory peptide targeting YAP-TEADs interaction. (In Vitro):Super-TDU TFA downregulates expression of YAP-TEADs target genes CTGF, CYR61, and CDX2. Super-TDU TFA inhibited cell viability and colony formation of GC cell lines MGC-803, BGC-823, and HGC27.(In Vivo):Super-TDU TFA (intravenous Injection; 50 μg/kg or 500 μg/kg; per day ) markedly decreases the sizes, weights of tumors, and YAP target genes in a dose-dependent manner. Super-TDU TFA (Intravenous Injection; 250 μg/kg 500 μg/kg) has the t1/2α of 0.78 hours and 0.82 hours; the Cmax of 6.12 ng/mL and 13.3 ng/mL; the CL of 7.41 ml/min/kg and 7.72 ml/min/kg for 250 μg/kg and 500 μg/kg in mice, respectively.

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Others

Other Targets

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5394

C239H371N66O71S

>98% (HPLC)

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Sequence:Ser-Val-Asp-Asp-His-Phe-Ala-Lys-Ser-Leu-Gly-Asp-Thr-Trp-Leu-Gln-Ile-Gly-Gly-Ser-Gly-Asn-Pro-Lys-Thr-Ala-Asn-Val-Pro-Gln-Thr-Val-Pro-Met-Arg-Leu-Arg-Lys-Leu-Pro-Asp-Ser-Phe-Phe-Lys-Pro-Pro-Glu

(-20℃)

With Ice Pack

≥ 2 years